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One hand holding the other, depicting pain in the joints
A Bacterial Culprit for Rheumatoid Arthritis
Scientists identified a species of Subdoligranulum that may drive disease.
A Bacterial Culprit for Rheumatoid Arthritis
A Bacterial Culprit for Rheumatoid Arthritis

Scientists identified a species of Subdoligranulum that may drive disease.

Scientists identified a species of Subdoligranulum that may drive disease.

News & Opinion

Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
Image of methylated DNA
Stress Increases Biological Age, But Recovery Can Revert It
Alejandra Manjarrez, PhD | Apr 21, 2023 | 2 min read
A new study relying on DNA methylation clocks suggests that the biological age of mouse and human cells can fluctuate in response to stressful events.
Image shows photorhabdus virulence cassettes (green) binding to insect cells (blue) prior to injection of payload proteins. 
Engineered Bacterial “Syringes” Can Deliver Drugs Into Human Cells
Rohini Subrahmanyam, PhD | Apr 20, 2023 | 4 min read
Researchers repurpose tiny bacterial injection systems to specifically inject a wide variety of proteins into human cells and living mice.
fMRI scan of two brains
New Brain Network Connecting Mind and Body Discovered
Natalia Mesa, PhD | Apr 19, 2023 | 4 min read
A new brain network responsible for complex movements may upend what we know about neural maps in primary motor areas
Histology of brain
Rare Autism-Linked Mutation Starves Growing Neurons of Essential Nutrients
Lauren Schenkman, Spectrum | Apr 18, 2023 | 4 min read
The mutation prevents certain amino acids from entering neurons, causing the cells to die early in development.
Green and brown illustration of cancer cells in front of a peach and yellow background.
Bacterial Tractor Beams Bring Radiation to Tumors
Rachael Moeller Gorman | Apr 17, 2023 | 3 min read
Colonizing tumors with engineered bacteria may allow researchers to target sites currently inaccessible to radionuclide therapy.
Histology showing IL-6 expression
Immune Molecule Alters Cellular Makeup of Human Brain Organoids
Charles Q. Choi, Spectrum | Apr 17, 2023 | 4 min read
The changes may help explain the link between maternal infection and autism, though more research is needed.
Bear paw dusted in snow
Hibernating Bears Provide Clue to Preventing Serious Clots in Humans
Natalia Mesa, PhD | Apr 13, 2023 | 3 min read
Low levels of the clotting factor HSP47 protect the sleeping giants from blood clots, and the same may be possible for humans and other mammals.
Bladder epithelial tissue, where cell junctions are shown in green and nuclei in blue. This was grown in vitro from cells taken from mice with chronic cystitis.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Alejandra Manjarrez, PhD | Apr 12, 2023 | 3 min read
Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.
Surface rendering of microscopy image showing two dendritic cells (green) communicating with a nociceptor neuron (violet).
How Cells in the Skin Team Up To Fight Pathogens
Rachael Moeller Gorman | Apr 12, 2023 | 4 min read
Immune cells and pain neurons form complex partnerships to protect our bodies from pathogens, new research reveals.
Artist’s rendition of orange DNA coiled around a blue histone protein.
“Cryptic Transcription”: How Aging Cells Express Fragments of Genes
Kamal Nahas, PhD | Apr 6, 2023 | 4 min read
Aging cells with weakened gene regulation spuriously transcribe RNAs, but their impact on health and longevity still needs to be examined.
Histological stain of in blue, red, and green of tumor
Self-Charging Battery Battles Tumors in Mice
Natalia Mesa, PhD | Apr 4, 2023 | 3 min read
A battery that charges itself in salty fluids starves tumors of oxygen, helping improve some drugs treat cancer, a study finds.
Illustration of newly discovered mechanism allowing kinesin to “walk” down a microtubule. A green kinesin molecule with an attached yellow fluorophore is shown passing through a blue laser as it rotates step by step along a red and purple microtubule, fueled by blue ATP molecules that are hydrolyzed into orange ADP and phosphate groups.
High-Resolution Microscope Watches Proteins Strut Their Stuff
Holly Barker, PhD | Mar 31, 2023 | 3 min read
Modification on a high-resolution fluorescent microscopy technique allow researchers to track the precise movements of motor proteins. 
Artist&rsquo;s rendering of bright orange <em >E. coli&nbsp;</em>bacteria
New Synthetic E. coli Is Immune to Bacteriophage Infection
Anna Napolitano, PhD | Mar 30, 2023 | 3 min read
Self-contained synthetic E. coli resistant to viral infection could prove invaluable to the biotechnology industry by increasing product consistency and reducing safety concerns. 
Artist&rsquo;s rendition of red SARS-CoV-2 coronaviruses floating near blue strands of DNA.
COVID-19 Infections May Reshape Genetic Landscape
Holly Barker, PhD | Mar 30, 2023 | 3 min read
SARS-CoV-2 infection triggers structural changes in the host cell’s DNA, which provide a molecular explanation for long COVID, a new study suggests. 
electron micrograph of grey cancer cell, with two red T cells stuck to the side
Translation of “Jumping Genes” Creates Cancer Therapy Targets
Natalia Mesa, PhD | Mar 29, 2023 | 4 min read
Researchers find many tumor-specific antigens form when cancer genes and transposable elements link up.
Image of the fly brain (grey) highlighting the population of neurons (pink) to which the gut-secreted peptide CCHa1 signals
A Protein-Rich Diet Helps Mice and Flies Sleep More Soundly: Study
Alejandra Manjarrez, PhD | Mar 24, 2023 | 3 min read
The effect appears to be mediated by a gut-secreted peptide that signals to neurons in the brain that modulate the response to mechanical vibrations.
Black and white portrait of Paul Berg
‘Godfather of Genetic Engineering’ Paul Berg Dies at 96
Lisa Winter | Mar 23, 2023 | 3 min read
Berg was awarded one-half of the Nobel Prize in Chemistry in 1980 for his work with recombinant DNA technology. 
Headshots of three people smiling and looking at camera.
2023 Brain Prize Awarded for Research on Synaptic Plasticity
Natalia Mesa, PhD | Mar 23, 2023 | 3 min read
The Lundbeck Foundation announces an international cohort of neuroscientists have collectively won the €1.3 million Brain Prize.
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