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Bladder epithelial tissue, where cell junctions are shown in green and nuclei in blue. This was grown in vitro from cells taken from mice with chronic cystitis.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice
Bladder ‘Memory’ Influences Urinary Tract Infection Recurrence in Mice

Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.

Urinary tract infections leave permanent epigenetic marks in the mouse bladder epithelium, reprogramming its response to subsequent infections, a study finds.

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Surface rendering of microscopy image showing two dendritic cells (green) communicating with a nociceptor neuron (violet).
How Cells in the Skin Team Up To Fight Pathogens
Rachael Moeller Gorman | Apr 12, 2023 | 4 min read
Immune cells and pain neurons form complex partnerships to protect our bodies from pathogens, new research reveals.
Histological stain of in blue, red, and green of tumor
Self-Charging Battery Battles Tumors in Mice
Natalia Mesa, PhD | Apr 4, 2023 | 3 min read
A battery that charges itself in salty fluids starves tumors of oxygen, helping improve some drugs treat cancer, a study finds.
Photograph of scientists working while wearing PPE
Contract Vivarium Facilities for Preclinical Discovery
The Scientist’s Creative Services Team and Mispro | 3 min read
Researchers rent contract vivarium space for greater experimental control, productivity, and reproducibility when developing new therapeutics.
Structure of a Chlamydomonas, green algae
Drugs Hitch a Ride on Algae for Targeted Delivery
Holly Barker, PhD | Feb 1, 2023 | 3 min read
A new microrobot uses algae to transport antibiotics into the lungs of mice with pneumonia.
Illustration showing microscopic algae swim through mouse lungs and deliver nanoparticles of an antibiotic attached to their surfaces
Infographic: Algae Robots Transport Antibiotics to Infected Tissues
Holly Barker, PhD | Feb 1, 2023 | 1 min read
Microscopic algae dotted with drug-filled nanoparticles may offer a more effective means of treatment than traditional delivery methods.
A nude (hairless) mouse, typically used in biomedical and drug discovery research methods that rely on immunodeficient mouse strains.
Brush Up: Humanized Mice: More than the Sum of Their Parts
Deanna MacNeil, PhD | 5 min read
Scientists study human health in vivo with modified mice that molecularly mimic human biology.
Closeup of a pair of hands in blue gloves holding a white mouse and injecting it with an amber colored liquid.
Opioids Recruit the Immune System to Cause Withdrawal Symptoms
Dan Robitzski | Jan 25, 2023 | 6 min read
A study finds that T cells induced by heroin cross the blood-brain barrier to wreak havoc on the brain, hinting at new ways to prevent withdrawal.
Microscopy image with blue and red neurons, where red indicates neurons involved in a memory engram
Asthma Drug Helps Mice Retrieve Memories “Lost” to Sleep Deprivation
Zunnash Khan | Jan 24, 2023 | 4 min read
A study finds roflumilast can reverse sleep deprivation–induced amnesia in mice, hinting at pathways to treating memory loss in people.
Staphylococcus aureus bacteria on the skin
The Scientist Speaks - Virulence Meets Metabolism: The Unique Evolution of Staphylococcus aureus
Niki Spahich, PhD | 1 min read
Anthony Richardson discusses what makes Staph especially dangerous for people with diabetes.
A younger-looking mouse next to an older-looking one
Epigenetic Manipulations Can Accelerate or Reverse Aging in Mice
Alejandra Manjarrez, PhD | Jan 12, 2023 | 4 min read
Repairing damaged DNA appears to drive aging by causing the loss of epigenetic information, but restoring that information reverses such effects, a study finds.
Pink neutrophils on a white background.
Mucus-Eating Gut Bacteria May Promote Fever After Cancer Treatment
Alejandra Manjarrez, PhD | Jan 5, 2023 | 3 min read
The expansion of mucus-degraders in the mouse gut—possibly due to poor nutrition—thins the colon’s mucus layer and may weaken defenses against blood-infecting microbes.
Delivering Combination Immunotherapies to Solid Tumors
LabTalk Podcast - A Modern Trojan Horse: Delivering Combination Immunotherapies to Solid Tumors 
The Scientist’s Creative Services Team and IsoPlexis | 1 min read
Katie McKenna discusses a combination CAR T and viral therapy that kills solid tumors.
A collection of images from prior stories, including illustrations of DNA, chromosomes, and various cells, microscopy images of cancer cells, and a photo of a mouse on a treadmill.
Our Favorite Cancer Stories of 2022
Dan Robitzski | Dec 27, 2022 | 4 min read
This year, cancer researchers uncovered a variety of ways that tumors can survive and spread, ranging from damaging their own DNA to exploiting the nearby microenvironment for nutrients.
Artist’s rendition of the molecular structure of a ribosome (blue and purple) as it produces a polypeptide chain (red) from an mRNA template (orange and gray), with tRNA molecules (dark purple) shuttling amino acids.
Specialized Sperm Ribosomes Are Key to Male Fertility in Mice
Dan Robitzski | Dec 15, 2022 | 4 min read
A previously unknown kind of ribosome is responsible for folding sperm proteins, which decay before fertilization if prepared by other ribosomes.
The Scientist Speaks Podcast - Episode 11
The Scientist’s Creative Services Team | 1 min read
A Path Back to Health: Immune Tolerance to Infectious Disease
Human hand with white glove holding a white mouse in a green background.
Study Traces a Neural Circuit Behind Green Light–Mediated Pain Relief
Alejandra Manjarrez, PhD | Dec 9, 2022 | 4 min read
A mouse study concludes color-detecting cones in the eye and a subset of neurons in the brain’s thalamus are why green light exposure has an analgesic effect.
Artist’s rendition of neural connections, with inactive neurons in the background
Ketamine Flips a “Switch” in Mice’s Brain Circuitry: Study
Andy Carstens | Dec 9, 2022 | 6 min read
After injecting moderate doses of the dissociative anesthetic into the animals, previously “awake” brain cells go dark, and those that had been dormant suddenly light up.
A mouse in front of an open sack of grain.
Mice Fed a Highly Processed Diet Are More Susceptible to the Flu
Alejandra Manjarrez, PhD | Nov 18, 2022 | 3 min read
It’s not clear why grain-fed mice are better able to recover after infection, but a study’s findings suggest food type may skew the results of animal studies.
Rendering of a light blue NLRP3 inflammasome against a black background
Inflammation in Brain’s Immune Cells Triggers Depressive Behavior in Mice
Dan Robitzski | Nov 17, 2022 | 5 min read
In stressful conditions, specialized protein complexes in microglia induce neurotoxic activity in astrocytes that leads to the change in behavior.
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