maternal-fetal interactions

Pregnancy-induced changes in the immune system are key to a successful birth. Understanding those changes could allow researchers to protect both mother and child.

Aberrant immune activation, the main cause of prematurity and stillbirths, could be preventable through interventions such as maternal vaccination. 

Before their own central clocks develop, the brains of fetal rats detect their mother’s metabolic cycle to help regulate the expression of certain genes.

An epigenome-wide association study found more than a dozen methylation changes in placental DNA that correlated with expectant mothers’ self-reports of depression and stress during their pregnancy.

Male placentas produce more proinflammatory molecules than female placentas, while people carrying male fetuses produce fewer antibodies in response to infection, a study finds.

Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.

Work in rodents shows that the bacteria living in a mother’s gut can produce immunomodulatory metabolites and influence the production of maternal antibodies—both of which can affect her offspring’s development.

Bacteria in the gut influence the production of antibodies and themselves secrete metabolites. In a pregnant woman, these compounds may influence immune development of her fetus.

Signaling pathways triggered by the mother’s immune system may cause complications during fetal development.

Study of 81 six-week-olds who were born by C-section or vaginal delivery didn’t show differences in the structure or function of their microbiota, despite contrary results from other studies on babies. 

The maternal gut microbiome guides neo- and postnatal immune system development, a mouse study shows. 

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