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Illustration of HIV virus
Viral Protein Behind Chronic Inflammation in People with HIV: Study
The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 
Viral Protein Behind Chronic Inflammation in People with HIV: Study
Viral Protein Behind Chronic Inflammation in People with HIV: Study

The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

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gene regulation

zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Holly Barker, PhD | Dec 1, 2022 | 4 min read
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
Blue 3D illustration of X-shaped chromosomes
X Chromosome Silenced in Some Cancers in Males
Natalia Mesa, PhD | Nov 11, 2022 | 3 min read
A study finds that XIST, the gene that shuts down one X chromosome in people who have two, is linked to cancer in males. 
The Inside Scoop on Successful ATAC-seq Experiments
Technique Talk: The Inside Scoop on Successful ATAC-seq Experiments
The Scientist’s Creative Services Team | 1 min read
Discover how to best map a cell’s epigenetic landscape
Ribonucleic acid strands consisting of nucleotides important for protein bio-synthesis
Katharina Höfer Probes the Machinery of Bacterial Gene Expression
Hannah Thomasy, PhD, Drug Discovery News | Jun 13, 2022 | 3 min read
The molecular biologist studies how chemical modifications to RNA building blocks change the way RNA regulates complex cellular processes.
An artist's rendition of an RNA molecule in light blue on a dark blue background
Same RNA Acts in Neurodegeneration and Cancer
Abby Olena, PhD | Oct 29, 2021 | 3 min read
The long noncoding RNA MINCR, implicated in ALS and Alzheimer’s disease as well as several types of cancer, appears to function differently when present at high versus low levels.
Integrating Single-Cell Transcriptomics and Proteomics: A New Era of Biological Research
Bridging the Gap: Integrating Single-Cell Transcriptomics and Proteomics
The Scientist Creative Services Team in Collaboration with IsoPlexis | 1 min read
An expert panel will discuss how a functional cell library confirms critical insights from previous omics studies. Additionally, they will introduce an innovative platform that connects single cell transcriptomics with functional proteomics for the first time.
Abstract illustration of DNA
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021 | 3 min read
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
A microscopy image of several endometrial stromal fibroblasts
Gene Offers Clue to How Human Labor Starts
Christie Wilcox, PhD | Aug 1, 2021 | 2 min read
Genes associated with preterm birth and protecting the fetus from the mother’s immune system appear to be regulated by HAND2.
Sample Preparation with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist’s Creative Services Team | 1 min read
In this webinar brought to you by 10x Genomics, experts will discuss how to successfully prepare nuclei suspensions for Single Cell Multiome ATAC + Gene Expression experiments.
illustration of multiple clocks arranged in the shape of a brain
How Early-Morning Light Exposure Makes Mice Less Depressed
Bianca Nogrady | Jul 22, 2021 | 4 min read
A light-sensitive gene involved in regulating the body clock may also influence mood, mediating the effect of light.
Cancer May Be Driven by DNA Outside of Chromosomes
Paul Mischel | Apr 1, 2021 | 10+ min read
In the last decade, researchers have come to realize that tumors harbor bits of extrachromosomal DNA that can drive malignancy.
Getting Started with Single Cell Multiomics: Simultaneous Epigenomic and Transcriptomic Profiling from the Same Cell
The Scientist’s Creative Services Team | 1 min read
In this webinar brought to you by 10x Genomics, experts will discuss tips for running Chromium Single Cell Multiome ATAC + Gene Expression experiments in your lab.
Infographic: The Role of Extrachromosomal DNA in Cancer
Paul Mischel | Apr 1, 2021 | 2 min read
Researchers are uncovering how circular bits of DNA found in some cancer cells can help tumors evolve and kill.
model organism, zebrafish, sponge, cell &molecular biology, genetics & genomics, enhancer, transcription, non-coding DNA, gene regulation, evolution
Regulators of Gene Activity in Animals Are Deeply Conserved
Amanda Heidt | Nov 6, 2020 | 5 min read
Enhancers, short regions of DNA that direct gene expression, of species separated by 700 million years of evolution worked interchangeably, according to a new study.
New Map Charts Genetic Expression Across Tissue Types, Sexes
Ashley Yeager | Sep 10, 2020 | 3 min read
A decade-long effort to probe gene regulation reveals differences between males and females, points to essential regulatory elements, and offers insight into past work on telomeres.
Cracking Down on Cancer: A Profile of Owen Witte
Diana Kwon | Apr 1, 2020 | 9 min read
Through his studies on cancer-causing viruses, the University of California, Los Angeles, professor has helped develop lifesaving treatments.
Image of the Day: Tomato Domestication
Amy Schleunes | Mar 30, 2020 | 1 min read
Scientists identify a transcription factor that plays a key role in increased fruit size.
Salk Institute Cofounder Melvin Cohn Dies
Ashley Yeager | Oct 26, 2018 | 2 min read
Cohn was a leader in gene regulation and immune system research and left a lasting legacy in La Jolla.
Uncovering Functions of Circular RNAs
Catherine Offord | Jul 16, 2017 | 10+ min read
Recent research has revealed many surprises about circular RNAs, from findings that they are translated in vivo to links between their expression and disease.
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